The effect of probiotics on the genotoxicity of furazolidone

Int J Food Microbiol. 2005 Jul 25;102(3):343-7. doi: 10.1016/j.ijfoodmicro.2004.11.029.

Abstract

Antigenotoxic activity of probiotic bacteria against furazolidone was studied using the short-term bacterial assay SOS chromotest, with Escherichia coli PQ37 as the test organism. The supernatants from probiotic and furazolidone co-incubation exhibited rather strong suppression on SOS induction produced by furazolidone on E. coli PQ 37 (sfiA: lacZ). Genotoxicity inhibition was found for all strains of the examined bacteria belonging to three genera. The highest genotoxicity inhibition was detected for Bifidobacterium lactis Bb-12 (92.0%) and for Lactobacillus acidophilus T20 (81.9%).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Infective Agents, Local / toxicity*
  • Bifidobacterium / genetics
  • Bifidobacterium / physiology*
  • Furazolidone / toxicity*
  • Lactobacillus / genetics
  • Lactobacillus / physiology*
  • Mutagenicity Tests
  • Probiotics / pharmacology*
  • SOS Response, Genetics / drug effects

Substances

  • Anti-Infective Agents, Local
  • Furazolidone