Ultrasound promoted synthesis of 5-hydroxy-5-trihalomethyl-4,5-dihydroisoxazoles and beta-enamino trihalomethyl ketones in water

Marcos A P Martins; Claudio M P Pereira; Wilson Cunico; Sidnei Moura; Fernanda A Rosa; Rodrigo L Peres; Pablo Machado; Nilo Zanatta; Helio G Bonacorso

doi:10.1016/j.ultsonch.2005.04.009

Ultrasound promoted synthesis of 5-hydroxy-5-trihalomethyl-4,5-dihydroisoxazoles and beta-enamino trihalomethyl ketones in water

Ultrason Sonochem. 2006 May;13(4):364-70. doi: 10.1016/j.ultsonch.2005.04.009. Epub 2005 Jul 12.

Authors

Marcos A P Martins¹, Claudio M P Pereira, Wilson Cunico, Sidnei Moura, Fernanda A Rosa, Rodrigo L Peres, Pablo Machado, Nilo Zanatta, Helio G Bonacorso

Affiliation

¹ Departamento de Química, Núcleo de Química de Heterociclos, NUQUIMHE, Universidade Federal de Santa Maria, 97105-900 Santa Maria, RS, Brazil. mmartins@base.ufsm.br

PMID: 16014337
DOI: 10.1016/j.ultsonch.2005.04.009

Abstract

A convenient method for the preparation of 5-hydroxy-5-trihalo-4,5-dihydroisoxazoles and beta-enamino trihalomethyl ketones, from the reaction of 1,1,1-trihalo-4-alkoxy-3-alken-2-ones with hydroxylamine and anilines, respectively, using water as solvent and under ultrasound irradiation is reported.