Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2005 Nov;94(5):3637-42.
doi: 10.1152/jn.00686.2005. Epub 2005 Jul 13.

Adaptive Exponential Integrate-And-Fire Model as an Effective Description of Neuronal Activity

Affiliations
Free article

Adaptive Exponential Integrate-And-Fire Model as an Effective Description of Neuronal Activity

Romain Brette et al. J Neurophysiol. .
Free article

Abstract

We introduce a two-dimensional integrate-and-fire model that combines an exponential spike mechanism with an adaptation equation, based on recent theoretical findings. We describe a systematic method to estimate its parameters with simple electrophysiological protocols (current-clamp injection of pulses and ramps) and apply it to a detailed conductance-based model of a regular spiking neuron. Our simple model predicts correctly the timing of 96% of the spikes (+/-2 ms) of the detailed model in response to injection of noisy synaptic conductances. The model is especially reliable in high-conductance states, typical of cortical activity in vivo, in which intrinsic conductances were found to have a reduced role in shaping spike trains. These results are promising because this simple model has enough expressive power to reproduce qualitatively several electrophysiological classes described in vitro.

Similar articles

See all similar articles

Cited by 223 articles

See all "Cited by" articles

MeSH terms

LinkOut - more resources

Feedback