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Review
, 44 (4), 235-58

Polyisoprenoids: Structure, Biosynthesis and Function

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Review

Polyisoprenoids: Structure, Biosynthesis and Function

Ewa Swiezewska et al. Prog Lipid Res.

Abstract

The polyisoprenoid alcohols and their derivatives are highlighted here. These linear polymers of isoprenoid residues are widespread in nature from bacteria to human cells. This review presents their structures, distribution and biogenesis. Attention will be focused on the biosynthesis of polyisoprenoid alcohols in plants in the context of two coexisting isoprenoid pathways, mevalonate and the recently described methylerythritol phosphate pathway. Structural aspects including modeling of the polyisoprenoid conformation will be presented and finally the postulated biological role of polyisoprenoid alcohols will be discussed including polyisoprenylation of proteins.

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