The pathology of cellular anti-stress mechanisms: a new frontier

Stress. 2004 Dec;7(4):243-9. doi: 10.1080/10253890400019706.


Exposure to stressors is an omnipresent variable for all living organisms, which have evolved anti-stress mechanisms to deal with the consequences of stress. The chaperoning systems are among these mechanisms, and their central components are the molecular chaperones that play important roles in protein biogenesis. Recent data suggest that failure of the chaperoning systems due to defective chaperones, for example, leads to pathology. Consequently, medical researchers and practitioners must now also consider the chaperoning systems, both as potentially major players in pathogenesis and as diagnostic-prognostic indicators.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Heat-Shock Proteins / physiology
  • Humans
  • Molecular Chaperones / physiology
  • Stress, Physiological*


  • Heat-Shock Proteins
  • Molecular Chaperones