Study of acrylamide in coffee using an improved liquid chromatography mass spectrometry method: Investigation of colour changes and acrylamide formation in coffee during roasting

Food Addit Contam. 2005 Mar;22(3):214-20. doi: 10.1080/02652030500109834.

Abstract

An improved analytical method for the determination of acrylamide in coffee is described using liquid chromatography coupled to mass spectrometric detection (LC-MS). A variety of instant, ground and laboratory roasted coffee samples were analysed using this method. The sample preparation entails extraction of acrylamide with methanol, purification with Carrez I and II solutions, evaporation and solvent change to water, and clean-up with an Oasis HLB solid-phase extraction (SPE) cartridge. The chromatographic conditions allowed separation of acrylamide and the remaining matrix co-extractives with accurate and precise quantification of acrylamide during MS detection in SIM mode. Recoveries for the spiking levels of 50, 100, 250 and 500?microg/kg ranged between 99 and 100% with relative standard deviations of less than 2%. The effects of roasting on the formation of acrylamide and colour development were also investigated at 150, 200 and 225 degrees C. Change in the CIE (Commission Internationale de l'Eclairage) a* colour value was found to show a good correlation with the change in acrylamide. CIE a* and acrylamide data was fitted to a non-linear logarithmic function for the estimation of acrylamide level in coffee. Measured acrylamide levels in commercial roasted coffees compared well with the predicted acrylamide levels from the CIE a* values.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acrylamide / analysis*
  • Chromatography, Liquid / methods
  • Coffee / chemistry*
  • Cooking / methods*
  • Food Contamination / analysis
  • Hot Temperature
  • Mass Spectrometry / methods
  • Methanol / chemistry
  • Pigmentation*
  • Reproducibility of Results
  • Solubility
  • Solvents / chemistry
  • Time Factors
  • Water / chemistry

Substances

  • Coffee
  • Solvents
  • Water
  • Acrylamide
  • Methanol