Correlation of retinal sensitivity measured with fundus-related microperimetry to visual acuity and retinal thickness in eyes with diabetic macular edema

Eye (Lond). 2006 Jul;20(7):805-9. doi: 10.1038/sj.eye.6702014. Epub 2005 Jul 15.


Aim: To determine whether significant correlations exist between retinal sensitivity measured by fundus-related microperimetry and the visual acuity and the foveal thickness measured by optical coherence tomography (OCT) in eyes with diabetic macular edema (DME).

Methods: A retrospective chart review of 32 eyes with DME and 17 normal healthy eyes that had undergone fundus-related microperimetry and OCT. The macular sensitivity was measured using the recently introduced fundus-related microperimeter, Micro Perimeter 1. The mean retinal sensitivities within the central 2 degrees and 10 degrees were correlated with the best-corrected visual acuity and OCT-measured foveal retinal thickness.

Results: The mean sensitivities in the central 2 degrees and 10 degrees were significantly lower in patients with DME than in normal subjects (P<0.0001). The mean retinal sensitivities in the central 2 degrees and 10 degrees were inversely correlated with visual acuity (r(2)=0.623, P<0.0001; r(2)=0.581, P<0.0001) and foveal thickness (r(2)=0.581, P<0.0001; r(2)=0.551, P<0.0001).

Conclusions: The mean retinal sensitivities measured with fundus-related microperimetry were significantly lower in eyes with DME than in normal eyes. Because a significant correlation of the microperimeter-determined retinal sensitivity to visual acuity and foveal thickness was observed, the retinal sensitivities obtained by fundus-related microperimetry may be another measure that can be used to assess the effects of DME.

MeSH terms

  • Adult
  • Aged
  • Diabetic Retinopathy / complications
  • Diabetic Retinopathy / pathology
  • Diabetic Retinopathy / physiopathology*
  • Fovea Centralis / pathology*
  • Fovea Centralis / physiopathology
  • Humans
  • Macular Edema / etiology
  • Macular Edema / pathology
  • Macular Edema / physiopathology*
  • Middle Aged
  • Prognosis
  • Retrospective Studies
  • Severity of Illness Index
  • Tomography, Optical Coherence
  • Visual Acuity / physiology*
  • Visual Field Tests
  • Visual Fields / physiology