Growth and survival signals controlling sympathetic nervous system development

Annu Rev Neurosci. 2005;28:191-222. doi: 10.1146/annurev.neuro.28.061604.135659.


The precise coordination of the many events in nervous system development is absolutely critical for the correct establishment of functional circuits. The postganglionic sympathetic neuron has been an amenable model for studying peripheral nervous system formation. Factors that control several developmental events, including multiple stages of axon extension, neuron survival and death, dendritogenesis, synaptogenesis, and establishment of functional diversity, have been identified in this neuron type. This knowledge allows us to integrate the various intricate processes involved in the formation of a functional sympathetic nervous system and thereby create a paradigm for understanding neuronal development in general.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Axons / physiology
  • Cell Death
  • Cell Differentiation
  • Cell Growth Processes / physiology*
  • Cell Survival / physiology
  • Models, Neurological
  • Neural Inhibition / physiology
  • Neurons / physiology*
  • Signal Transduction / physiology*
  • Sympathetic Nervous System / cytology*
  • Sympathetic Nervous System / growth & development
  • Sympathetic Nervous System / physiology*
  • Synapses / physiology