Validation of a patient-administered questionnaire to measure the activity impairment experienced by women with uncomplicated urinary tract infection: the Activity Impairment Assessment (AIA)

Health Qual Life Outcomes. 2005 Jul 15;3:42. doi: 10.1186/1477-7525-3-42.

Abstract

Background: To validate a questionnaire to assess the activity impairment associated with uncomplicated urinary tract infection (uUTI).

Methods: The Activity Impairment Assessment (AIA) assesses the amount of time an individual's work or regular activities have been impaired as a result of their UTI. The measure was completed by 276 women with uUTI who had participated in a prospective, open-label, non-comparative multi-centre clinical trial of CIPRO XR (extended-release ciprofloxacin). Baseline scores on the King's Health Questionnaire (KHQ) and clinical symptom evaluations were collected for validation purposes.

Results: An exploratory factor analysis showed that all items loaded > 0.84 on a single component. This uni-dimensional structure was supported by Rasch analysis. The AIA was found to have excellent levels of internal consistency (Cronbach's alpha = 0.93), convergent validity (all rs > .70) and divergent validity (rs = .078). The AIA displayed excellent discriminant validity in relation to clinical evaluations, and was found to be responsive to change across all clinical evaluations.

Conclusion: The unidimensional AIA shows high levels of internal reliability, convergent and divergent validity, discriminant validity and responsiveness. It is an excellent tool for measuring activity impairment in UTI.

Publication types

  • Research Support, Non-U.S. Gov't
  • Validation Study

MeSH terms

  • Activities of Daily Living
  • Adult
  • Anti-Infective Agents / therapeutic use
  • Ciprofloxacin / therapeutic use
  • Clinical Trials as Topic
  • Female
  • Humans
  • Middle Aged
  • Multicenter Studies as Topic
  • Psychometrics / instrumentation*
  • Quality of Life*
  • Sickness Impact Profile*
  • Surveys and Questionnaires*
  • Urinary Tract Infections / drug therapy
  • Urinary Tract Infections / physiopathology*
  • Urinary Tract Infections / psychology

Substances

  • Anti-Infective Agents
  • Ciprofloxacin