Dopaminergic modulation of horizontal-cell-axon-terminal receptive field size in the mammalian retina

Vision Res. 2006 Feb;46(4):467-74. doi: 10.1016/j.visres.2005.05.010. Epub 2005 Jul 14.


Receptive fields of gap junction-coupled axon terminals of B-type horizontal cells of isolated rabbit retinae were measured by recording light responses to slit shaped light stimuli at different eccentricities from the recording site. The D1/D5 agonist SKF-38393 and the membrane permeant second messenger 8-bromo-cAMP caused decreases of space constants by 20% while the D1/D5 antagonist SCH-23390 increased space constants by 25%. The results of this study indicate that axon terminal receptive fields of the rabbit retina can be modulated by D1/D5 receptor activation based on a cAMP-mediated mechanism. The data also suggest the presence of endogenous dopamine as an agent for axon terminal receptive field size modulation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / pharmacology
  • Animals
  • Dopamine / physiology*
  • Dopamine Agonists / pharmacology
  • Female
  • Gap Junctions / physiology
  • Male
  • Photic Stimulation / methods
  • Presynaptic Terminals / physiology*
  • Presynaptic Terminals / ultrastructure
  • Rabbits
  • Receptors, Dopamine D1 / physiology
  • Receptors, Dopamine D5 / physiology
  • Retina / physiology*
  • Visual Fields / drug effects
  • Visual Fields / physiology*


  • Dopamine Agonists
  • Receptors, Dopamine D1
  • Receptors, Dopamine D5
  • 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
  • Dopamine