Protein-protein interactions in the tetraspanin web

Physiology (Bethesda). 2005 Aug:20:218-24. doi: 10.1152/physiol.00015.2005.


Tetraspanins are evolutionarily conserved membrane proteins that tend to associate laterally with one another and to cluster dynamically with numerous partner proteins in membrane microdomains. Consequently, members of this family are involved in the coordination of intracellular and intercellular processes, including signal transduction; cell proliferation, adhesion, and migration; cell fusion; and host-parasite interactions.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Antigens, CD / chemistry*
  • Antigens, CD / metabolism*
  • Humans
  • Membrane Proteins / chemistry*
  • Membrane Proteins / metabolism*
  • Protein Structure, Tertiary
  • Signal Transduction / physiology


  • Antigens, CD
  • Membrane Proteins