Mechanical signals, IGF-I gene splicing, and muscle adaptation

Physiology (Bethesda). 2005 Aug:20:232-8. doi: 10.1152/physiol.00004.2005.


Combining physiological and molecular biology methods made it possible to identify and characterize a local muscle growth/repair factor (MGF). Following resistance exercise, MGF "kick starts" muscle hypertrophy and is important in local tissue repair. Loss of muscle mass in old age and certain diseases is associated with an impaired ability to express MGF.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptation, Physiological / physiology*
  • Alternative Splicing / physiology*
  • Animals
  • Humans
  • Insulin-Like Growth Factor I / genetics*
  • Mechanotransduction, Cellular / physiology*
  • Muscle, Skeletal / physiology*


  • Insulin-Like Growth Factor I