Skeletal muscle glucose uptake during exercise: how is it regulated?

Physiology (Bethesda). 2005 Aug;20:260-70. doi: 10.1152/physiol.00012.2005.


The increase in skeletal muscle glucose uptake during exercise results from a coordinated increase in rates of glucose delivery (higher capillary perfusion), surface membrane glucose transport, and intracellular substrate flux through glycolysis. The mechanism behind the movement of GLUT4 to surface membranes and the subsequent increase in transport by muscle contractions is largely unresolved, but it is likely to occur through intracellular signaling involving Ca(2+)-calmodulin-dependent protein kinase, 5'-AMP-activated protein kinase, and possibly protein kinase C.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Energy Metabolism / physiology*
  • Glucose / metabolism*
  • Humans
  • Muscle, Skeletal / metabolism*
  • Physical Exertion / physiology*


  • Glucose