Drug resistance in brain diseases and the role of drug efflux transporters

Nat Rev Neurosci. 2005 Aug;6(8):591-602. doi: 10.1038/nrn1728.


Resistance to drug treatment is an important hurdle in the therapy of many brain disorders, including brain cancer, epilepsy, schizophrenia, depression and infection of the brain with HIV. Consequently, there is a pressing need to develop new and more effective treatment strategies. Mechanisms of resistance that operate in cancer and infectious diseases might also be relevant in drug-resistant brain disorders. In particular, drug efflux transporters that are expressed at the blood-brain barrier limit the ability of many drugs to access the brain. There is increasing evidence that drug efflux transporters have an important role in drug-resistant brain disorders, and this information should allow more efficacious treatment strategies to be developed.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Brain Chemistry / physiology*
  • Brain Diseases / drug therapy*
  • Brain Diseases / physiopathology*
  • Drug Resistance / physiology*
  • Humans
  • Membrane Transport Proteins / physiology*


  • Membrane Transport Proteins