Abstract
Interleukin-4 (IL-4) is a cytokine produced by T(H)2 type helper T cells and by mast cells, basophils, and eosinophils. This cytokine can elicit many responses, some of which are associated with allergy and asthma. Studies with long-term cell lines and primary cells have revealed differences in the signaling between these two experimental systems. Understanding these differences is important because therapeutic strategies targeting IL-4 and its signaling pathways are currently being tested to treat allergy and asthma.
MeSH terms
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Animals
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Dimerization
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Humans
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Interleukin-13 Receptor alpha1 Subunit
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Interleukin-4 / pharmacology
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Interleukin-4 / physiology*
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Models, Biological*
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Protein-Tyrosine Kinases / physiology
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Receptors, Interleukin / chemistry
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Receptors, Interleukin / physiology
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Receptors, Interleukin-13
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Receptors, Interleukin-4 / chemistry
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Receptors, Interleukin-4 / drug effects
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Receptors, Interleukin-4 / physiology*
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Signal Transduction / drug effects
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Signal Transduction / physiology*
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Th2 Cells / physiology
Substances
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IL13RA1 protein, human
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Interleukin-13 Receptor alpha1 Subunit
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Receptors, Interleukin
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Receptors, Interleukin-13
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Receptors, Interleukin-4
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Interleukin-4
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Protein-Tyrosine Kinases