Correlation analysis of the in-clinic and telephone batteries from the AREDS cognitive function ancillary study. AREDS Report No. 15

Ophthalmic Epidemiol. 2005 Aug;12(4):271-7. doi: 10.1080/09286580591003815.


Purpose: To determine whether the AREDS Telephone Battery can be substituted for the In-Clinic Cognitive Function Battery to assess cognitive function, so that participants could still provide follow-up information without having to come to the clinic.

Methods: Correlation analysis was performed on scores of the following in-clinic and telephone administrations: 1) Modified Mini-Mental State Examination (3MS), conducted in person vs. Telephone Interview Cognitive Status (TICS-M); 2) Wechsler Memory Scale-III (WMS-III), Logical Memory I and II; 3) Digits Backwards (a sub-test of the WMS-R); 4) Verbal Fluency; and 5) Letter Fluency (F,A,S).

Results: A total of 1,738 AREDS participants completed an In-Clinic Battery and a Telephone Battery within twelve months. Significant positive correlations were found for all tests, ranging from rho = 0.89 between the 3MS and TICS-M scores (95% CI; 0.88 - 0.90), to rho = 0.71 for Letter Fluency (95% CI; 0.68 - 0.74).

Conclusion: The linear relationships between the In-Clinic Battery and Telephone Battery scores support the hypothesis that the Telephone Battery is an appropriate substitute for participants who are unable to complete an in-clinic assessment of cognitive function.

Publication types

  • Multicenter Study

MeSH terms

  • Aged
  • Aged, 80 and over
  • Antioxidants / administration & dosage
  • Cataract / prevention & control
  • Cognition Disorders / diagnosis*
  • Cross-Sectional Studies
  • Diet
  • Female
  • Humans
  • Macular Degeneration / prevention & control
  • Male
  • Mass Screening / methods*
  • Mental Status Schedule
  • Middle Aged
  • Neuropsychological Tests
  • Outpatient Clinics, Hospital
  • Population Surveillance / methods*
  • Predictive Value of Tests
  • Prospective Studies
  • Sensitivity and Specificity
  • Telephone
  • Zinc / administration & dosage


  • Antioxidants
  • Zinc