Id family of helix-loop-helix proteins in cancer

Nat Rev Cancer. 2005 Aug;5(8):603-14. doi: 10.1038/nrc1673.


Over the past few decades, biologists have identified key molecular signatures associated with a wide range of human cancers. Recently, animal models have been particularly useful in establishing whether such signatures have functional relevance; the overexpression of pro-oncogenic or loss of anti-oncogenic factors have been evaluated for their effects on various tumour models. The aim of this review is to analyze the potential role of the inhibitor of DNA binding (Id) proteins in cancer and examine whether deregulated Id activity is tumorigenic and contributes to hallmarks of malignancy, such as loss of differentiation (anaplasia), unrestricted proliferation and neoangiogenesis.

Publication types

  • Review

MeSH terms

  • Anaplasia / physiopathology
  • Biomarkers, Tumor*
  • Cell Proliferation
  • Helix-Loop-Helix Motifs / physiology*
  • Humans
  • Inhibitor of Differentiation Protein 1
  • Models, Animal
  • Neoplasms / physiopathology*
  • Neovascularization, Pathologic / physiopathology
  • Repressor Proteins / physiology*
  • Transcription Factors / physiology*


  • Biomarkers, Tumor
  • ID1 protein, human
  • Inhibitor of Differentiation Protein 1
  • Repressor Proteins
  • Transcription Factors