Alpha-synuclein immunohistochemistry in two cases of co-occurring idiopathic Parkinson's disease and motor neuron disease

Mov Disord. 2005 Nov;20(11):1515-20. doi: 10.1002/mds.20604.


We report on two cases of sporadic idiopathic Parkinson's disease with motor neuron disease co-occurring in the same individuals. Pathological analysis revealed the presence of Lewy bodies in brainstem nuclei and basal forebrain consistent with Lewy body disease (LBD), as well as motor neuron degeneration and argyrophilic grain disease. We compared our two cases to all previously published pathological cases of combined LBD and motor neuron degeneration.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Brain / metabolism
  • Brain / pathology
  • Female
  • Humans
  • Immunohistochemistry / methods
  • Male
  • Motor Neuron Disease / complications*
  • Motor Neuron Disease / metabolism*
  • Motor Neuron Disease / pathology
  • Neurofilament Proteins / metabolism
  • Parkinson Disease / complications*
  • Parkinson Disease / metabolism*
  • Parkinson Disease / pathology
  • Ubiquitin / metabolism
  • alpha-Synuclein / metabolism*


  • Neurofilament Proteins
  • Ubiquitin
  • alpha-Synuclein