Tissue plasminogen activator irrigation to facilitate removal of subretinal hemorrhage during vitrectomy

Ophthalmic Surg. 1992 May;23(5):361-3.


I report removing a large submacular hemorrhage by means of vitrectomy combined with use of tissue plasminogen activator (tPA) to facilitate clot removal. Four months postoperatively, the vision was 20/100 and the retina was flat, with a very thin layer of residual hemorrhage and pigmentary alteration in the macula. Although the long-term prognosis is guarded, this case does suggest that tPA may be a useful adjunct in managing selected cases of subretinal hemorrhage associated with macular degeneration.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Blood Loss, Surgical
  • Female
  • Fundus Oculi
  • Humans
  • Prognosis
  • Retinal Hemorrhage / therapy*
  • Therapeutic Irrigation
  • Tissue Plasminogen Activator / therapeutic use*
  • Visual Acuity
  • Vitrectomy*


  • Tissue Plasminogen Activator