Is high cerebral perfusion pressure and cerebral flow predictive of impending seizures in preeclampsia? A case report

Hypertens Pregnancy. 2005;24(1):59-63. doi: 10.1081/PRG-45776.


Transcranial Doppler ultrasound was used to demonstrate elevated estimated cerebral perfusion pressure (CPP) and cerebral flow index (CFI) in a preeclamptic patient. She subsequently developed eclampsia. After magnesium sulfate therapy her CPP and CFI were within the normal range and she did not experience further seizures. This finding suggests that cerebral overperfusion may be at least one of the etiologies involved in the pathogenesis of eclampsia.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Blood Flow Velocity
  • Cerebrovascular Circulation / physiology
  • Eclampsia / diagnosis
  • Eclampsia / drug therapy
  • Female
  • Humans
  • Intracranial Hypertension / diagnostic imaging*
  • Intracranial Hypertension / physiopathology
  • Magnesium Sulfate / therapeutic use
  • Parity
  • Pre-Eclampsia / blood
  • Pre-Eclampsia / diagnostic imaging*
  • Pre-Eclampsia / physiopathology
  • Predictive Value of Tests
  • Pregnancy
  • Pregnancy Outcome*
  • Pregnancy Trimester, Third
  • Risk Assessment
  • Seizures / diagnosis*
  • Seizures / physiopathology
  • Ultrasonography, Doppler, Transcranial*


  • Magnesium Sulfate