A population-based case-control study of isolated ocular coloboma

Ophthalmic Epidemiol. 2005 Jun;12(3):191-7. doi: 10.1080/09286580590969699.

Abstract

Aims: To attempt the detection of possible etiological factors in the origin of isolated ocular, mainly iris coloboma.

Methods: The data set of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980-2002, was used. Exposure data and family history were based on (1) prospective medical records, (2) retrospective maternal information, and (3) information obtained by regional nurses at home visit.

Results: Of 46 cases, 40 were affected with iris coloboma and 19 had bilateral manifestation. The positive family history indicated a hereditary origin in 4.3% (2/46) of cases. An association was found between the isolated ocular coloboma and hydroxyethylrutoside treatment (adjusted POR with 95% CI: 5.4, 2.2-12.9). Another association was seen between isolated ocular coloboma and hypothyroidism (adjusted OR with 95% CI = 12.6, 3.0-52.7), but it was based only on two cases.

Conclusions: It is necessary to study the preventable environmental factors in the origin of these ocular defects.

MeSH terms

  • Abnormalities, Drug-Induced / etiology
  • Birth Weight
  • Case-Control Studies
  • Choroid / abnormalities*
  • Coloboma / chemically induced
  • Coloboma / epidemiology*
  • Coloboma / genetics
  • Female
  • Gestational Age
  • Humans
  • Hungary / epidemiology
  • Hydroxyethylrutoside / adverse effects
  • Infant
  • Infant, Newborn
  • Iris / abnormalities*
  • Male
  • Maternal Age
  • Optic Nerve / abnormalities*
  • Registries

Substances

  • Hydroxyethylrutoside