Prevalence and Risk Factors for Human Immunodeficiency Virus-Associated Neurocognitive Impairment, 1996 to 2002: Results From an Urban Observational Cohort

J Neurovirol. 2005 Jul;11(3):265-73. doi: 10.1080/13550280590952790.

Abstract

To assess prevalence and risk factors for human immunodeficiency virus (HIV)-related neurocognitive impairment (NCI), the authors performed a 7-year survey in the period 1996 to 2002. A total of 432 patients were examined. HIV-related NCI was diagnosed in 238 patients (55.1%), meeting the HIV dementia (HIV-D) criteria in 45 (10.4%). The prevalence of both NCI and HIV-D did not change significantly during the study period. Compared with patients without NCI, patients with NCI were older (40.4 versus 38.2 years; P = .003), had a higher prevalence of positive HCV serology (61.1% versus 38.9%; P = .003), and a lower nadir CD4 cell count (156 versus 222 cells/microl; P < .001). Compared with patients seen during 1996 to 1999, patients with NCI seen during 2000 to 2002 were older (40.7 versus 38.8 years; P = .004), had a less advanced disease stage (previous acquired immunodeficiency syndrome [AIDS] 28.8% versus 65.7%; P < .001) and a higher nadir CD4 count (174 versus 132 cells/microl; P = .026). This study showed an unchanged prevalence of both HIV-related NCI and HIV-D in the period 1996 to 2002. The authors found evidences for new additional potential risk factors for HIV-related NCI (older age, lower nadir CD4 count, positive hepatitis C virus [HCV] serology), and for a change of risk factors for NCI in the late highly active antiretroviral therapy (HAART) era (older age, less advanced disease, higher nadir CD4 count).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • AIDS Dementia Complex / epidemiology*
  • AIDS Dementia Complex / immunology
  • AIDS Dementia Complex / pathology
  • Adult
  • Age Factors
  • CD4 Lymphocyte Count
  • Cognition Disorders / epidemiology*
  • Cognition Disorders / immunology
  • Cognition Disorders / pathology
  • Cohort Studies
  • Comorbidity
  • Female
  • Health Surveys
  • Hepatitis C / epidemiology
  • Humans
  • Italy / epidemiology
  • Male
  • Nervous System Diseases
  • Prevalence
  • Risk Factors