LDL-cholesterol predicts negative coronary artery remodelling in diabetic patients: an intravascular ultrasound study

Eur Heart J. 2005 Nov;26(21):2307-12. doi: 10.1093/eurheartj/ehi420. Epub 2005 Jul 21.


Aims: To investigate the relationship between coronary artery remodelling and glycaemic and lipid profiles in diabetic patients.

Methods and results: Intravascular ultrasound analyses of 131 angiographically non-significant coronary stenoses in 80 diabetic patients were performed. The remodelling index (RI) was calculated as the ratio between total vessel area at target site and total vessel area at proximal reference, and was assessed in two ways: as a continuous variable, and as a binary categorical variable: RI<1 namely, negative remodelling (group I), or RI> or =1 (group II). Percentage cross-sectional narrowing was 57+/-13%. On average, RI was 0.93+/-0.13. Coronary shrinkage was found in 94 (71.7%) lesions. Significant inverse correlations were demonstrated between RI and total cholesterol (r=-0.26, P=0.003), apolipoprotein-B (r=-0.23, P=0.01) and LDL-cholesterol (r=-0.3, P=0.001) levels. Multivariable lineal regression analysis identified LDL-cholesterol as the only independent predictor of RI (P=0.001).

Conclusion: Negative remodelling is a frequent finding in diabetics and it is associated with LDL-cholesterol levels. This may contribute to the diffuse coronary artery disease observed in diabetic patients.

Publication types

  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Blood Glucose / metabolism
  • Cholesterol, LDL / blood*
  • Coronary Stenosis / blood*
  • Coronary Stenosis / diagnostic imaging
  • Coronary Stenosis / pathology
  • Coronary Vessels / pathology*
  • Diabetic Angiopathies / blood*
  • Diabetic Angiopathies / diagnostic imaging
  • Diabetic Angiopathies / pathology
  • Female
  • Humans
  • Immunosuppressive Agents / administration & dosage
  • Insulin Resistance
  • Male
  • Prospective Studies
  • Sirolimus / administration & dosage
  • Stents
  • Ultrasonography


  • Blood Glucose
  • Cholesterol, LDL
  • Immunosuppressive Agents
  • Sirolimus