Treatment of verruca plantaris with a combination of topical fluorouracil and salicylic acid

J Am Podiatr Med Assoc. Jul-Aug 2005;95(4):366-9. doi: 10.7547/0950366.

Abstract

A medical record review was conducted to determine the clinical outcome and average time to resolution of verruca plantaris in 20 patients treated with twice-daily applications of either 0.5% or 5.0% topical fluorouracil combined with topical 17% and 40% salicylic acid. Seven patients used 0.5% fluorouracil, and 13 used 5.0% fluorouracil. All of the lesions were sharply debrided at regular 1- or 2-week intervals. All 20 patients achieved full clinical resolution in a mean +/- SD of 82.5 +/- 56.6 days. Three patients (15%) had recurrent lesions, which subsequently resolved with repeated treatment. Two patients (10%) developed local dermatitis, which resolved with temporary discontinuation of the medication and the addition of a topical corticosteroid. It was observed that the twice-daily application of topical fluorouracil and salicylic acid is a safe and effective treatment for verruca plantaris.

MeSH terms

  • Administration, Cutaneous
  • Adolescent
  • Adult
  • Antimetabolites / administration & dosage*
  • Antimetabolites / therapeutic use
  • Child
  • Drug Therapy, Combination
  • Female
  • Fluorouracil / administration & dosage*
  • Fluorouracil / therapeutic use
  • Foot Diseases / drug therapy*
  • Humans
  • Keratolytic Agents / administration & dosage*
  • Keratolytic Agents / therapeutic use
  • Male
  • Middle Aged
  • Retrospective Studies
  • Salicylic Acid / administration & dosage*
  • Salicylic Acid / therapeutic use
  • Treatment Outcome
  • Warts / drug therapy*

Substances

  • Antimetabolites
  • Keratolytic Agents
  • Salicylic Acid
  • Fluorouracil