Plasma ropivacaine levels during awake intracranial surgery

J Neurosurg Anesthesiol. 2005 Jul;17(3):153-5. doi: 10.1097/01.ana.0000167446.56839.a4.

Abstract

Plasma ropivacaine levels produced by routine scalp infiltration for field block were assayed in eight patients undergoing awake intracranial surgery. Levels peaked within approximately 13 minutes, indicating rapid systemic absorption of ropivacaine. Potentially toxic plasma drug levels were achieved in three of eight patients, although no untoward effects attributable to elevated levels of ropivacaine were observed. Clinical vigilance is indicated during scalp infiltration with ropivacaine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Amides / adverse effects
  • Amides / blood*
  • Amides / pharmacokinetics
  • Anesthesia, Local*
  • Anesthetics, Local / adverse effects
  • Anesthetics, Local / blood*
  • Anesthetics, Local / pharmacokinetics
  • Chromatography, Gas
  • Dose-Response Relationship, Drug
  • Female
  • Half-Life
  • Humans
  • Male
  • Middle Aged
  • Neurosurgical Procedures*
  • Pilot Projects
  • Ropivacaine
  • Scalp
  • Wakefulness

Substances

  • Amides
  • Anesthetics, Local
  • Ropivacaine