Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 366 (9482), 321-31

Sjögren's Syndrome

Affiliations
Review

Sjögren's Syndrome

Robert I Fox. Lancet.

Abstract

Sjögren's syndrome is a chronic autoimmune disorder of the exocrine glands with associated lymphocytic infiltrates of the affected glands. Dryness of the mouth and eyes results from involvement of the salivary and lacrimal glands. The accessibility of these glands to biopsy enables study of the molecular biology of a tissue-specific autoimmune process. The exocrinopathy can be encountered alone (primary Sjögren's syndrome) or in the presence of another autoimmune disorder such as rheumatoid arthritis, systemic lupus erythematosus, or progressive systemic sclerosis. A new international consensus for diagnosis requires objective signs and symptoms of dryness including a characteristic appearance of a biopsy sample from a minor salivary gland or autoantibody such as anti-SS-A. Exclusions to the diagnosis include infections with HIV, human T-lymphotropic virus type I, or hepatitis C virus. Therapy includes topical agents to improve moisture and decrease inflammation. Systemic therapy includes steroidal and non-steroidal anti-inflammatory agents, disease-modifying agents, and cytotoxic agents to address the extraglandular manifestations involving skin, lung, heart, kidneys, and nervous system (peripheral and central) and haematological and lymphoproliferative disorders. The most difficult challenge in diagnosis and therapy is patients with symptoms of fibromyalgia (arthralgia, myalgia, fatigue) and oral and ocular dryness in the presence of circulating antinuclear antibodies.

Similar articles

  • Sjögren Syndrome
    S Srinivasan et al. Compr Ophthalmol Update 8 (4), 205-12. PMID 17999834. - Review
    Sjögren syndrome is a chronic autoimmune disorder of the exocrine glands with associated lymphocytic infiltration of the affected glands. The exocrinopathy can be encount …
  • Management of Patients Presenting With Sjogren's Syndrome
    PJ Venables. Best Pract Res Clin Rheumatol 20 (4), 791-807. PMID 16979538. - Review
    Sjogren's syndrome is an autoimmune exocrinopathy that predominantly affects salivary and lachrymal glands, leading to dry eyes and mouth. The most common clinical proble …
  • [Sjögren's Syndrome]
    T Witte. Z Rheumatol 73 (1), 49-61. PMID 24554256.
    Sjögren's syndrome is an autoimmune disease characterized by lymphocytic infiltration of the tear and salivary glands leading to dryness of the mouth and eyes. The awaren …
  • Lessons From Diseases Mimicking Sjögren's Syndrome
    M Ramos-Casals et al. Clin Rev Allergy Immunol 32 (3), 275-83. PMID 17992594. - Review
    Sjögren's syndrome (SS) is a systemic autoimmune disease that mainly affects the exocrine glands and usually presents as persistent dryness of the mouth and eyes because …
  • Sjögren's Syndrome in Dermatology
    RI Fox et al. Clin Dermatol 24 (5), 393-413. PMID 16966020. - Review
    Sjogren's Syndrome (SS) is a systemic autoimmune disease characterized by dry eyes (keratoconjunctivis sicca) and dry mouth (xerostomia). To fulfill diagnostic criteria, …
See all similar articles

Cited by 317 PubMed Central articles

See all "Cited by" articles

Publication types

MeSH terms

LinkOut - more resources

Feedback