Divide and conquer: division of labor by B-1 B cells

Immunity. 2005 Jul;23(1):1-2. doi: 10.1016/j.immuni.2005.07.001.


Capsular polysaccharides enhance bacterial virulence. In this issue of Immunity, demonstrate a division of labor between the B-1 B cell subsets: natural antibodies from B-1a cells limit infection by Streptococcus pneumoniae, whereas B-1b cells generate the anticapsule-induced response that prevents fatal infection.

Publication types

  • Comment
  • Review

MeSH terms

  • Animals
  • B-Lymphocyte Subsets / immunology*
  • Bacterial Capsules / immunology*
  • Mice
  • Streptococcus pneumoniae / immunology*
  • Streptococcus pneumoniae / pathogenicity
  • Virulence