Ganodermin, an antifungal protein from fruiting bodies of the medicinal mushroom Ganoderma lucidum

Peptides. 2006 Jan;27(1):27-30. doi: 10.1016/j.peptides.2005.06.009. Epub 2005 Jul 21.


A 15-kDa antifungal protein, designated ganodermin, was isolated from the medical mushroom Ganoderma lucidum. The isolation procedure utilized chromatography on DEAE-cellulose, Affi-gel blue gel, CM-Sepharose and Superdex 75. Ganodermin was unadsorbed on DEAE-cellulose and adsorbed on Affi-gel blue gel and CM-Sepharose. Ganodermin inhibited the mycelial growth of Botrytis cinerea, Fusarium oxysporum and Physalospora piricola with an IC50 value of 15.2 microM, 12.4 microM and 18.1 microM, respectively. It was devoid of hemagglutinating, deoxyribonuclease, ribonuclease and protease inhibitory activities.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Antifungal Agents / chemistry*
  • Antifungal Agents / pharmacology*
  • Botrytis / drug effects
  • Chromatography, Ion Exchange
  • Dose-Response Relationship, Drug
  • Fruiting Bodies, Fungal / chemistry*
  • Fungal Proteins / isolation & purification*
  • Fungal Proteins / pharmacology
  • Molecular Sequence Data
  • Reishi / chemistry*


  • Antifungal Agents
  • Fungal Proteins