3-(2-Aminoethyl)pyridine analogs as alpha4beta2 nicotinic cholinergic receptor ligands

Bioorg Med Chem Lett. 2005 Oct 1;15(19):4308-12. doi: 10.1016/j.bmcl.2005.06.053.

Abstract

An examination of several 3-(2-aminoethyl)pyridine analogs suggests that they likely orient at alpha4beta2 nicotinic cholinergic receptors in a different fashion than their correspondingly substituted nicotine analogs.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Crystallization
  • Drug Evaluation, Preclinical
  • Humans
  • Ligands
  • Molecular Structure
  • Nicotine / analogs & derivatives
  • Nicotine / metabolism
  • Protein Binding
  • Pyridines / chemical synthesis*
  • Pyridines / chemistry
  • Pyridines / metabolism
  • Receptors, Nicotinic / chemistry*
  • Receptors, Nicotinic / metabolism
  • Solvents
  • Structure-Activity Relationship

Substances

  • Ligands
  • Pyridines
  • Receptors, Nicotinic
  • Solvents
  • nicotinic receptor alpha4beta2
  • Nicotine