Magnetic resonance imaging findings in pre-clinical Creutzfeldt-Jakob disease

Int J Neurosci. 2005 Aug;115(8):1219-25. doi: 10.1080/00207450590914491.


The diagnosis of probable Creutzfeldt-Jakob disease (CJD) requires compatible clinical manifestations, typical electroencephalographical findings, and 14.3.3 protein positive in cerebrospinal fluid. Actually, MRI findings are not necessary, but they may support this diagnosis. The authors report a patient with definitive diagnosis of CJD who showed in a first MRI study performed two years before the clinical onset of the disease the same hyperintensities in caudate nuclei that were found in the last MRI. The authors think that these findings could be useful in detecting asymptomatic patients who need more extensive study and following.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Aged, 80 and over
  • Atrophy / pathology
  • Basal Ganglia / blood supply
  • Basal Ganglia / diagnostic imaging
  • Basal Ganglia / pathology
  • Brain / blood supply
  • Brain / diagnostic imaging
  • Brain / pathology*
  • Brain Ischemia / pathology
  • Caudate Nucleus / blood supply
  • Caudate Nucleus / diagnostic imaging
  • Caudate Nucleus / pathology
  • Cerebrospinal Fluid Proteins / metabolism
  • Creutzfeldt-Jakob Syndrome / cerebrospinal fluid*
  • Creutzfeldt-Jakob Syndrome / diagnosis*
  • Creutzfeldt-Jakob Syndrome / physiopathology
  • Electroencephalography
  • Fatal Outcome
  • Female
  • Humans
  • Magnetic Resonance Angiography / methods
  • Magnetic Resonance Imaging*
  • Tomography, X-Ray Computed


  • Cerebrospinal Fluid Proteins