Probiotics reduce enterohemorrhagic Escherichia coli O157:H7- and enteropathogenic E. coli O127:H6-induced changes in polarized T84 epithelial cell monolayers by reducing bacterial adhesion and cytoskeletal rearrangements

Infect Immun. 2005 Aug;73(8):5183-8. doi: 10.1128/IAI.73.8.5183-5188.2005.


The aim of this study was to determine if probiotics reduce epithelial injury following exposure to Escherichia coli O157:H7 and E. coli O127:H6. The pretreatment of intestinal (T84) cells with lactic acid-producing bacteria reduced the pathogen-induced drop in transepithelial electrical resistance. These findings demonstrate that probiotics prevent epithelial injury induced by attaching-effacing bacteria.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Actinin / metabolism
  • Bacterial Adhesion / physiology*
  • Cytoskeleton / metabolism*
  • Epithelial Cells / metabolism*
  • Epithelial Cells / microbiology
  • Escherichia coli Infections / metabolism
  • Escherichia coli Infections / therapy
  • Escherichia coli O157 / metabolism*
  • Humans
  • Lactobacillus acidophilus / metabolism
  • Probiotics / metabolism*


  • Actinin