Secondary diabetes mellitus: late complication of glycogen storage disease type 1b

J Pediatr Endocrinol Metab. 2005 Jun;18(6):617-9. doi: 10.1515/jpem.2005.18.6.617.


We report a 22 year-old male with glycogen storage disease type 1 (GSD-1) who developed diabetes mellitus secondary to pancreatic islet beta-cell insufficiency. Diabetes mellitus should be considered among the late complications of GSD-1. The pathogenesis of the conversion, from a disease characterized by hypoglycemia to a disease dominated by hyperglycemia, is discussed.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Diabetes Mellitus / etiology*
  • Diabetes Mellitus / pathology
  • Glycogen Storage Disease Type I / complications*
  • Glycogen Storage Disease Type I / pathology
  • Humans
  • Hyperglycemia / etiology
  • Islets of Langerhans / diagnostic imaging
  • Islets of Langerhans / pathology
  • Male
  • Pancreas / diagnostic imaging
  • Pancreatic Function Tests
  • Tomography, X-Ray Computed