A Role of SAND-family Proteins in Endocytosis

Biochem Soc Trans. 2005 Aug;33(Pt 4):606-8. doi: 10.1042/BST0330606.

Abstract

Caenorhabditis elegans has recently been used as an attractive model system to gain insight into mechanisms of endocytosis in multicellular organisms. A combination of forward and reverse genetics has identified a number of new membrane trafficking factors. Most of them have mammalian homologues which function in the same transport events. We describe a novel C. elegans gene sand-1, whose loss of function causes profound endocytic defects in many tissues. SAND-1 belongs to a conserved family of proteins present in all eukaryotic species, whose genome is sequenced. However, SAND family has not been previously characterized in metazoa. Our comparison of C. elegans SAND-1 and its yeast homologue, Mon1p, showed a conserved role of the SAND-family proteins in late steps of endocytic transport.

MeSH terms

  • Animals
  • Caenorhabditis elegans / physiology
  • Caenorhabditis elegans Proteins / pharmacology*
  • Caenorhabditis elegans Proteins / physiology
  • Endocytosis / physiology*

Substances

  • Caenorhabditis elegans Proteins
  • SAND-1 protein, C elegans