Use of hyaluronidase in the treatment of granulomatous hyaluronic acid reactions or unwanted hyaluronic acid misplacement

Dermatol Surg. 2005 Aug;31(8 Pt 1):893-7. doi: 10.1097/00042728-200508000-00001.


Background: In the past, reactions or misplacement of soft tissue fillers has been fraught with anxiety because time has been the main thrust for improvement in spite of ancillary treatments. Hyaluronidase is an enzyme that dissolves hyaluronic acid in the skin and also assists in the management of granulomatous foreign-body reactions to hyaluronic acid. These reactions may be caused by allergy to the material or immunologic response to the protein contaminants in the hyaluronic acid preparations. Dissolution of material in erroneous placement of material and in allergic reactions can be a time saver and a deterrent to patient dissatisfaction.

Objective: To evaluate the use of hyaluronidase in the treatment of both allergic reactions and the erroneous misplacement of hyaluronic acid in the skin.

Methods: A case of persistent granulomatous reaction to injectable hyaluronic acid and a case of hyaluronic acid erroneous misplacement with their successful subsequent treatments using intracutaneous hyaluronidase are reported, along with illustrative examples of hyaluronidase use.

Results: The use of hyaluronidase reduced the patient discomfort within 24 to 48 hours, deterring any patient anxiety or patient dissatisfaction.

Conclusions: Hyaluronidase has a place in the treatment of allergic reactions to hyaluronic acid [corrected] and in the erroneous misplacement of the material.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Cosmetic Techniques / adverse effects
  • Diagnosis, Differential
  • Drug Hypersensitivity / diagnosis*
  • Drug Hypersensitivity / drug therapy
  • Drug Hypersensitivity / etiology
  • Drug Hypersensitivity / pathology
  • Facial Dermatoses / chemically induced
  • Facial Dermatoses / diagnosis*
  • Facial Dermatoses / drug therapy
  • Facial Dermatoses / pathology
  • Female
  • Granuloma, Foreign-Body / chemically induced
  • Granuloma, Foreign-Body / diagnosis*
  • Granuloma, Foreign-Body / drug therapy
  • Granuloma, Foreign-Body / pathology
  • Humans
  • Hyaluronic Acid / administration & dosage
  • Hyaluronic Acid / adverse effects*
  • Hyaluronoglucosaminidase / administration & dosage
  • Injections, Subcutaneous
  • Middle Aged
  • Skin Aging*


  • Hyaluronic Acid
  • Hyaluronoglucosaminidase