Protein-protein interaction and functionTRPC channels

Pflugers Arch. 2005 Oct;451(1):116-24. doi: 10.1007/s00424-005-1442-2. Epub 2005 Jul 26.


Since their identification in the concluding years of the last century, the mammalian transient receptor potential (canonical) (TRPC) channels have remained in the limelight as the primary candidates for the Ca(2+) entry pathway activated by the hormones, growth factors, and neurotransmitters that exert their effect through activation of PLC. Although TRPC channels have been shown clearly to mediate, at least in part, receptor-activated Ca(2+) entry in literally all cell types, several of their central characteristics, as recorded in expression systems using recombinant channels, differ from those of the native receptor-dependent Ca(2+) influx channels. The present review attempts to highlight the interaction of TRPC channels with other proteins, which may explain the variability of TRPC channel activation and regulatory mechanisms observed with the native and recombinant channels. These include the homologous and heterotopous interactions of TRPC channel isoforms, the interaction of TRPC channels with calmodulin, PLCgamma, IP(3) receptors, and with scaffolding proteins like InaD, EBP50/NEHRF, caveolin, Janctate and Homers.

Publication types

  • Review

MeSH terms

  • Animals
  • Calcium / metabolism*
  • Calcium Channels / metabolism
  • Calcium-Binding Proteins / metabolism
  • Calmodulin / metabolism
  • Carrier Proteins / metabolism
  • Cell Membrane / metabolism
  • Endoplasmic Reticulum / metabolism
  • Homer Scaffolding Proteins
  • Humans
  • Inositol 1,4,5-Trisphosphate Receptors
  • Membrane Proteins / metabolism
  • Mixed Function Oxygenases / metabolism
  • Muscle Proteins / metabolism
  • Protein Interaction Mapping
  • Protein Isoforms / physiology
  • Protein Structure, Quaternary
  • Receptors, Cytoplasmic and Nuclear / metabolism
  • SNARE Proteins / metabolism
  • TRPC Cation Channels / physiology*
  • Type C Phospholipases / metabolism
  • src-Family Kinases / metabolism


  • Calcium Channels
  • Calcium-Binding Proteins
  • Calmodulin
  • Carrier Proteins
  • Homer Scaffolding Proteins
  • ITPR1 protein, human
  • Inositol 1,4,5-Trisphosphate Receptors
  • Membrane Proteins
  • Muscle Proteins
  • Protein Isoforms
  • Receptors, Cytoplasmic and Nuclear
  • SNARE Proteins
  • TRPC Cation Channels
  • Mixed Function Oxygenases
  • ASPH protein, human
  • src-Family Kinases
  • Type C Phospholipases
  • Calcium