Itching for progress

Clin Exp Dermatol. 2005 Sep;30(5):471-3. doi: 10.1111/j.1365-2230.2005.01852.x.


The study of itch remains a neglected field, with a number of barriers limiting satisfactory therapy in the majority of instances. We review recent advances, focusing on the identification of the neural pathways, distinct from pain, that signal itch; methods to measure itch as scratch in humans; and the identification of a role for H4 receptors in mediating itch (in the mouse).

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Histamine Antagonists / therapeutic use
  • Humans
  • Mice
  • Neural Pathways / physiopathology
  • Pruritus / diagnosis
  • Pruritus / drug therapy
  • Pruritus / physiopathology*
  • Receptors, Histamine / physiology


  • Histamine Antagonists
  • Receptors, Histamine