Health-related quality of life deficits associated with diabetes and comorbidities in a Canadian National Population Health Survey

Qual Life Res. 2005 Jun;14(5):1311-20. doi: 10.1007/s11136-004-6640-4.


Objective: To assess the impact of comorbid heart disease, stroke and arthritis on health-related quality of life (HRQL) in people with diabetes in the general Canadian population.

Methods: Data were collected as part of the 1996-1997 Canadian National Population Health Survey. HRQL was assessed using overall Health Utilities Index Mark 3 (HUI3) and single attribute utility scores. Respondents (N = 66,093) were classified into 1 of 16 groups based on the presence or absence of diabetes, heart disease, stroke, and arthritis, in all possible combinations and HRQL scores were compared using analysis of covariance.

Results: Overall HUI3 scores for respondents with diabetes alone (0.88, 95% CI: 0.87-0.89) were lower than controls (0.92: 95% CI: 0.92-0.92, p < 0.001). Overall HUI3 scores for diabetes in combination with heart disease (0.77, 95% CI: 0.74-0.79), arthritis (0.78, 95% CI: 0.77-0.79) or stroke (0.79, 95% CI: 0.74-0.85) were considerably lower than diabetes alone. Triplets of comorbidities were associated with overall HRQL deficits of approximately 0.26-0.30, relative to controls.

Conclusions: The illness burden experienced by individuals with diabetes is not only associated with diabetes itself, but largely with comorbid medical conditions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Activities of Daily Living
  • Adult
  • Aged
  • Arthritis / complications*
  • Arthritis / psychology
  • Canada
  • Chronic Disease
  • Comorbidity
  • Diabetes Complications / physiopathology*
  • Diabetes Complications / psychology
  • Diabetes Mellitus / physiopathology*
  • Diabetes Mellitus / psychology
  • Female
  • Heart Diseases / complications*
  • Heart Diseases / psychology
  • Humans
  • Male
  • Middle Aged
  • Quality of Life*
  • Sickness Impact Profile*
  • Stroke / complications*
  • Stroke / psychology