[Studying the mechanisms of ladasten action]

Eksp Klin Farmakol. May-Jun 2005;68(3):3-6.
[Article in Russian]

Abstract

The effect of N-(2-adamantyl)-N-(p-bromophenyl)amine (ladasten) on the behavior of MR and MNRA inbred rats with different emotional-stress reaction (ESR) phenotypes was studied in the conventional open-field test. Ladasten (30 mg/kg, i.p.) produced anxiolytic effect in MR rates, while not influencing MNRA animals. At the same time, a model stress induced disorder in the regulation of 3 H-diazepam binding to the benzodiazepine site of GABA(A) receptor in MR (but not in MNRA) rats. Ladasten administered in the anxiolytic dose prevented stress-induced changes in reception at this site.

Publication types

  • English Abstract

MeSH terms

  • Adamantane / administration & dosage
  • Adamantane / analogs & derivatives*
  • Adamantane / pharmacology
  • Animals
  • Anti-Anxiety Agents / administration & dosage
  • Anti-Anxiety Agents / pharmacology*
  • Asthenia / physiopathology
  • Behavior, Animal / drug effects*
  • Brain / drug effects
  • Diazepam / pharmacology
  • Male
  • Rats
  • Rats, Inbred Strains
  • Receptors, GABA-A / drug effects*
  • Stress, Psychological / physiopathology*

Substances

  • Anti-Anxiety Agents
  • N-(2-adamantyl)-N-p-bromophenylamine
  • Receptors, GABA-A
  • Adamantane
  • Diazepam