[Molecular mechanism of diabetic retinopathy: role of advanced glycation end products(AGEs) and their receptor (RAGE) in the pathogenesis of diabetic retinopathy]

Nippon Ganka Gakkai Zasshi. 2005 Jun;109(6):338-45.
[Article in Japanese]

Abstract

There is a growing body of evidence that advanced glycation end product-receptor(AGE-RAGE) interaction elicits oxidative stress generation, thus indicating that it is involved in the pathogenesis of diabetic retinopathy. Inhibition of AGE formation or blockade of the downstream RAGE signaling is a promising therapeutic strategy for treatment of patients with diabetic retinopathy.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis
  • Diabetic Retinopathy / etiology*
  • Diabetic Retinopathy / therapy
  • Endothelial Cells
  • Epoprostenol / biosynthesis
  • Eye Proteins / physiology
  • Glycation End Products, Advanced* / physiology
  • Humans
  • Microcirculation / cytology
  • Neovascularization, Pathologic
  • Nerve Growth Factors / physiology
  • Oxidative Stress
  • Receptor for Advanced Glycation End Products
  • Receptors, Immunologic / physiology
  • Retinal Vein Occlusion / etiology
  • Retinal Vessels / cytology
  • Serpins / physiology
  • Signal Transduction / physiology
  • Vascular Endothelial Growth Factor A / metabolism

Substances

  • Eye Proteins
  • Glycation End Products, Advanced
  • Nerve Growth Factors
  • Receptor for Advanced Glycation End Products
  • Receptors, Immunologic
  • Serpins
  • Vascular Endothelial Growth Factor A
  • pigment epithelium-derived factor
  • Epoprostenol