Gorham's disease is described as a rare form of massive non-familiar idiopathic osteolysis with a self-limiting nature, where the simil-angiomatous tissue destroys the bone, that is substituted by fibrous tissue. One case of Gorham's disease is presented, that is interesting because of the sites in which the pathology is localized and because of its multicentricity. The authors reached a diagnosis by carefully studying clinical and laboratory evidence as well as imaging and anatomo-histopathological findings, confirmed by the data reported in the literature.