A new RNA synthetic method with a 2'-O-(2-cyanoethoxymethyl) protecting group

Org Lett. 2005 Aug 4;7(16):3477-80. doi: 10.1021/ol051151f.


A novel method for the synthesis of RNA oligomers with 2-cyanoethoxymethyl (CEM) as the 2'-hydroxyl protecting group has been developed. The new method allows the synthesis of oligoribonucleotides with an efficiency and final purity comparable to that obtained in DNA synthesis. [structure: see text]

MeSH terms

  • Base Sequence
  • Models, Chemical
  • Molecular Sequence Data
  • Molecular Structure
  • Nitriles / chemistry*
  • RNA / chemical synthesis*
  • RNA / chemistry


  • Nitriles
  • RNA