Single-step synthesis of D3h-symmetric bicyclooxacalixarenes

Org Lett. 2005 Aug 4;7(16):3505-7. doi: 10.1021/ol051180q.

Abstract

Bicyclooxacalixarenes are obtained in up to 95% yield by condensation of phloroglucinol with electron-poor meta-dihalogenated benzenes or pyridines. Single-crystal X-ray analysis reveals that these compounds adopt highly symmetrical, all-1,3-alternate cage-like structures. [structure: see text]