Innate and adaptive immunity: the yin and yang of celiac disease

Immunol Rev. 2005 Aug;206:219-31. doi: 10.1111/j.0105-2896.2005.00294.x.


Celiac disease is a multigenetic complex inflammatory disorder with an autoimmune component, induced by gluten, a protein found in wheat. It is a unique human disease model to dissect the innate and adaptive immune mechanisms underlying T-cell-mediated tissue destruction and the development of T-cell lymphoma in conditions of chronic T-cell activation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Autoimmune Diseases / immunology*
  • Celiac Disease / genetics
  • Celiac Disease / immunology*
  • Humans
  • Immunity, Innate*