Genes That Mediate Breast Cancer Metastasis to Lung

Nature. 2005 Jul 28;436(7050):518-24. doi: 10.1038/nature03799.

Abstract

By means of in vivo selection, transcriptomic analysis, functional verification and clinical validation, here we identify a set of genes that marks and mediates breast cancer metastasis to the lungs. Some of these genes serve dual functions, providing growth advantages both in the primary tumour and in the lung microenvironment. Others contribute to aggressive growth selectively in the lung. Many encode extracellular proteins and are of previously unknown relevance to cancer metastasis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Breast Neoplasms / genetics*
  • Breast Neoplasms / pathology*
  • Cell Line, Tumor
  • Gene Expression Profiling*
  • Gene Expression Regulation, Neoplastic / genetics*
  • Humans
  • Lung Neoplasms / genetics*
  • Lung Neoplasms / pathology
  • Lung Neoplasms / secondary*
  • Neoplasm Metastasis / genetics*
  • RNA, Neoplasm / analysis
  • RNA, Neoplasm / genetics
  • Reproducibility of Results
  • Transcription, Genetic / genetics

Substances

  • RNA, Neoplasm