Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2005 Jun;59(3):89-92.
doi: 10.18926/AMO/31980.

Effects of Valerian Extract on the Sleep-Wake Cycle in Sleep-Disturbed Rats

Affiliations
Free article

Effects of Valerian Extract on the Sleep-Wake Cycle in Sleep-Disturbed Rats

Kazuaki Shinomiya et al. Acta Med Okayama. .
Free article

Abstract

The present study was performed to investigate the effects of valerian extract on the sleep-wake cycle using sleep-disturbed model rats. A significant shortening in sleep latency was observed with valerian extract at doses of 1000 and 3000 mg/kg. On the other hand, valerian extract had no significant effects on total times of wakefulness, non-rapid eye movement (non-REM) sleep, or REM sleep, even at a dose of 3000 mg/kg. Valerian extract at doses of 1000 and 3000 mg/kg showed a significant increase in the delta activity during non-REM sleep. In conclusion, valerian extract may be useful as an herbal medicine having not only sleep-inducing effects but also sleep quality-enhancement effects.

Similar articles

See all similar articles

LinkOut - more resources

Feedback