[Impact of exogenic proteolytic enzymes on bacteria]

Antibiot Khimioter. 2004;49(12):9-13.
[Article in Russian]


The impact of papain, trypsin and the enzyme complex vobenzyme on formation of biofilms by grampositive and gramnegative bacteria was studied. The enzymes were shown to inhibit the biofilm formation. When applilied to the formed associations, the enzymes potentiated the effect of antibiotics on the bacteria located in them. An increase in the antimicrobial effect of various nonrelated antibiotics was not connected with a change in the bacteria susceptibility but likely resulted from higher bioavailability of the drugs in the presence of the enzymes.

Publication types

  • English Abstract

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Biofilms / drug effects*
  • Biofilms / growth & development
  • Drug Synergism
  • Gram-Negative Bacteria / growth & development*
  • Gram-Positive Bacteria / growth & development*
  • Peptide Hydrolases / pharmacology*


  • Anti-Bacterial Agents
  • Peptide Hydrolases