Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2005 Sep 16;309(5742):1861-4.
doi: 10.1126/science.1113611. Epub 2005 Jul 28.

HST2 Mediates SIR2-independent Life-Span Extension by Calorie Restriction

Free article

HST2 Mediates SIR2-independent Life-Span Extension by Calorie Restriction

Dudley W Lamming et al. Science. .
Free article


Calorie restriction (CR) extends the life span of numerous species, from yeast to rodents. Yeast Sir2 is a nicotinamide adenine dinucleotide (NAD+-dependent histone deacetylase that has been proposed to mediate the effects of CR. However, this hypothesis has been challenged by the observation that CR can extend yeast life span in the absence of Sir2. Here, we show that Sir2-independent life-span extension is mediated by Hst2, a Sir2 homolog that promotes the stability of repetitive ribosomal DNA, the same mechanism by which Sir2 extends life span. These findings demonstrate that the maintenance of DNA stability is critical for yeast life-span extension by CR and suggest that, in higher organisms, multiple members of the Sir2 family may regulate life span in response to diet.

Comment in

Similar articles

See all similar articles

Cited by 94 articles

See all "Cited by" articles

Publication types

MeSH terms

LinkOut - more resources