Design and development of polymers for gene delivery

Nat Rev Drug Discov. 2005 Jul;4(7):581-93. doi: 10.1038/nrd1775.


The lack of safe and efficient gene-delivery methods is a limiting obstacle to human gene therapy. Synthetic gene-delivery agents, although safer than recombinant viruses, generally do not possess the required efficacy. In recent years, a variety of effective polymers have been designed specifically for gene delivery, and much has been learned about their structure-function relationships. With the growing understanding of polymer gene-delivery mechanisms and continued efforts of creative polymer chemists, it is likely that polymer-based gene-delivery systems will become an important tool for human gene therapy.

Publication types

  • Review

MeSH terms

  • Animals
  • Cyclodextrins
  • Drug Design
  • Gene Transfer Techniques*
  • Genetic Therapy
  • Genetic Vectors
  • Humans
  • Imidazoles / chemistry
  • Polymers*


  • Cyclodextrins
  • Imidazoles
  • Polymers