Effects of sildenafil on blue-on-yellow and white-on-white Humphrey perimetry in 3 months regular use

Eye (Lond). 2006 Jul;20(7):810-3. doi: 10.1038/sj.eye.6702017. Epub 2005 Jul 29.


Purpose: To assess the effects of sildenafil on blue-on-yellow (B/Y) and white-on-white (W/W) Humphrey perimetry in a group of men with erectile dysfunction in 3 months regular use.

Methods: In this prospective study, 14 patients with erectile dysfunction received 50 mg doses of sildenafil (Viagra, Pfizer) two times per week regularly for 3 months. Patients underwent best-corrected visual acuity (BCVA), colour vision, anterior segment and fundus examination, and B/Y and W/W Humphrey perimetry in each eye before and after sildenafil treatment. Changes in mean deviations (MD) were compared separately for both eyes.

Results: No significant changes from baseline were observed in BCVA and colour vision after sildenafil treatment. The anterior segment and fundus examinations revealed no abnormalities. There was no change on B/Y and W/W Humphrey visual field. MD values of B/Y and W/W Humphrey perimetry remained nonsignificant for both eyes after 3 months regular use of sildenafil (P=0.133, and 0.092, respectively, for right, and P=0.221 and 0.925, respectively, for left eyes).

Conclusion: Oral sildenafil used regularly for 3 months produced no effect on B/Y and W/W Humphrey perimetry.

MeSH terms

  • 3',5'-Cyclic-GMP Phosphodiesterases / antagonists & inhibitors
  • Administration, Oral
  • Adult
  • Color Perception / drug effects*
  • Drug Administration Schedule
  • Erectile Dysfunction / drug therapy*
  • Erectile Dysfunction / physiopathology
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Phosphodiesterase Inhibitors / administration & dosage
  • Phosphodiesterase Inhibitors / therapeutic use*
  • Piperazines / administration & dosage
  • Piperazines / therapeutic use*
  • Prospective Studies
  • Purines / administration & dosage
  • Purines / therapeutic use
  • Sildenafil Citrate
  • Sulfones / administration & dosage
  • Sulfones / therapeutic use*
  • Time Factors
  • Treatment Outcome
  • Visual Field Tests / methods*
  • Visual Fields / drug effects*
  • Visual Fields / physiology


  • Phosphodiesterase Inhibitors
  • Piperazines
  • Purines
  • Sulfones
  • Sildenafil Citrate
  • 3',5'-Cyclic-GMP Phosphodiesterases