Synthesis and evaluation of bifunctional chelating agents derived from bis(2-aminophenylthio)alkane for radioimaging with 99mTc

Bhupender S Chhikara; Nitin Kumar; Vibha Tandon; Anil K Mishra

doi:10.1016/j.bmc.2005.04.073

Synthesis and evaluation of bifunctional chelating agents derived from bis(2-aminophenylthio)alkane for radioimaging with 99mTc

Bioorg Med Chem. 2005 Aug 1;13(15):4713-20. doi: 10.1016/j.bmc.2005.04.073.

Authors

Bhupender S Chhikara¹, Nitin Kumar, Vibha Tandon, Anil K Mishra

Affiliation

¹ Dr. B.R. Ambedkar Center for Biomedical Research, University of Delhi, Delhi 110007, India.

PMID: 16052734
DOI: 10.1016/j.bmc.2005.04.073

Abstract

Novel bifunctional chelating agents bearing an aromatic rigid backbone have been synthesized and characterized on the basis of spectroscopic techniques. These macrocyclic multidentate chelating agents were conjugated with monoclonal antibody which forms stable complexes with 99mTc with high radiochemical purity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkanes / chemistry*
Chelating Agents / chemical synthesis*
Chelating Agents / chemistry
Chelating Agents / pharmacology*
Isotope Labeling
Molecular Structure
Sulfides / chemistry*
Technetium / analysis*

Substances

Alkanes
Chelating Agents
Sulfides
Technetium